Twenty-four points and 17 places separate the two teams in the table, with the hosts rooted to the bottom while Lille sit third after 18 matches.
Jerome Arpinon made no secret of his disappointment after Nimes were thrashed by a fellow relegation rival in Strasbourg, who hit Les Crocodiles for five without reply on Wednesday evening.
As if conceding a quintet of goals was not already bad enough, Nimes also gave away three penalties on the night - one of which from Ludovic Ajorque was saved by Baptiste Reynet - and Arpinon did not hold back after the game as he blasted his side's performance at the Stade de la Meinau.
The 5-0 drubbing left Nimes down in 20th with the prospect of survival becoming increasingly unlikely, with four points separating Arpinon's men from safety after Nantes and Dijon both managed to pick up a point from their midweek encounters.
No team in the league has shipped more goals than Nimes (39) so far, and Les Crocodiles have also lost more times at home than any other club in the 2020-21 Ligue 1 campaign - falling to defeat seven times in nine games on familiar territory.
Even if Nimes were to produce an unthinkable result against Lille, three points would not be enough for the league's basement side to climb out of the bottom three, and they are now coming up against a Dogues team with a point to prove after a surprise defeat on Wednesday.
Lille's Ligue 1 title bid suffered a significant blow in their first match of 2021 as they lost 2-1 to European outsiders Angers, who struck twice early on through Romain Thomas before Burak Yilmaz pulled one back for Les Dogues.
The defeat at the Stade Pierre-Mauroy - their first loss at home in the league campaign - abruptly ended Lille's seven-game unbeaten run in the French top flight as they lost ground on Lyon at the top of the table.
Christophe Galtier's men are now three points off the pace after Lyon prevailed against Lens and dropped to third following Paris Saint-Germain's stalemate with Saint-Etienne, with only goal difference separating Lille from the champions.
Les Dogues failed to kick off the New Year in ideal fashion, but a trip to Nimes could prove to be the perfect tonic for Galtier and co as they bid to return to winning ways and keep the pressure on the top two.
Nimes last took the spoils in a meeting with Lille back in February 1999, although Les Dogues had Victor Osimhen's equaliser to thank as they rescued a 2-2 draw in their most recent bout with the division's basement side last season.
Nimes Ligue 1 form: LLLDLL
Lille Ligue 1 form: WWWDWL
Lille form (all competitions): LWWDWL
Arpinon affirmed that he will only select players willing to fight for the shirt after Wednesday's humiliation at Strasbourg, so it would not be a surprise to see the likes of Lamine Fomba, Niclas Eliasson and Yassine Benrahou return to the first XI.
Should Sanches not be cleared for a return to action just yet, Boubakary Soumare is another option for change in the engine room.
Nimes possible starting lineup:
Reynet; Burner, Briancon, Guessoum, Meling; Fomba, Cubas; Ferhat, Benrahou, Eliasson; Roux
Lille possible starting lineup:
Maignan; Djalo, Fonte, Botman, Bradaric; Ikone, Andre, Soumare, Bamba; David, Yilmaz
We say: Nimes 0-3 Lille
Arpinon is sure to be fearing for his future in the Nimes dugout after a truly dismal night in Strasbourg, and the visit of Lille could not have come at a worse time for the hosts. Les Dogues will be determined to prove that their defeat to Angers was nothing more than a minor blip, and the title hopefuls should record a routine win on Saturday.