The Football Association has confirmed that general secretary Alex Horne will leave his post at the end of January 2015.
The 42-year-old, who joined English football's governing body in 2004, has been in the role for the past four years.
"This is probably the toughest decision I have made during my career. But after 11 fantastic years at The FA, I have decided to move on," he told the FA's official website.
"At the age of 42, the time is right for me to look for a change of direction and I will be leaving the organisation at the end of January next year.
"I am incredibly proud to have worked for The FA for over a decade in many differing roles. It's been a privilege to have played my part in the financing, build and opening of Wembley Stadium and the National Football Centre at St. George's Park, both of which will provide a huge benefit for the game."
FA chairman Greg Dyke has revealed that he will now look to appoint a successor to Horne.