Meanwhile, Glory head into Wednesday's fixture looking to reduce the seven-point deficit to ninth-placed Wellington Phoenix.
No team currently sitting in the top seven of the A-League table have put together successive victories in their last six outings, something which could have hindered Melbourne City's efforts to end the campaign in first place.
However, three wins and two draws from their last five fixtures have left City in a commanding position as they bid to move further clear of Central Coast Mariners.
Still holding two games in hand on many of the chasing pack, Patrick Kisnorbo will be confident that their three-point lead can be extended over the coming weeks.
Jamie Maclaren netted his 20th goal of the campaign in the 3-1 win over Newcastle Jets on April 29, but Kisnorbo will be pleased that other members of the squad are still contributing in the final third.
While he has not been at his best this season, Andrew Nabbout has netted twice in his last three outings, including in the last game.
As far as Perth Glory are concerned, they are eager to end a five-match winless streak as soon as possible as they bid to avoid losing ground on the top nine.
A goalless draw with Macarthur appears to be a step in the right direction, but their only success in 11 contests came at home to bottom-of-the-table Jets.
Although goals were not an issue during the early stages of the campaign, Richard Garcia's side have now netted just twice in five fixtures.
Top goalscorer Bruno Fornaroli has failed to contribute a strike since March 24, a drought spanning six games.
Having been withdrawn at half time versus Macarthur, Joel Chianese could drop back down to the Glory substitutes' bench.
Barring any late fitness issues, Kisnorbo could stick with the same players which cruised to victory against the Jets.
Kisnorbo was able to rest four key men during the closing stages of that contest, increasing the chances of an unchanged Melbourne XI.
Florin Berenguer is an alternative in the centre of midfield if Kisnorbo wants to introduce fresh legs into the side.
Perth Glory possible starting lineup:
Reddy; Geria, Aspropotamitis, Bodnar, Ota; Kilkenny, Malik; Ikonomidis, Castro, Armiento; Fornaroli
Melbourne City possible starting lineup:
Glover; Galloway, Griffiths, Good, Jamieson; Luna, O'Neill, Metcalfe; Nabbout, Maclaren, Noone
We say: Perth Glory 1-3 Melbourne City
While City have been far from perfect in recent months, they are the only team challenging at the top who are showing any kind of consistency.
With the freedom to express themselves, we expect a comfortable win for the visitors against opponents who will begin the contest on the back foot.