The annual pre-season curtain raiser has a slight twist to it this year - it is not pre-season for FA Cup winners Wigan, who have already begun their league campaign following relegation to the second tier.
The Latics beat Barnsley 4-0 in their Championship opener and manager Owen Coyle could name the same side that began Wigan's quest for an immediate return to the Premier League so impressively.
However, the Irishman may be tempted to hand a debut to new signing James McClean, who arrived from Sunderland in a reported £2m deal this week.
Moyes has given an indication of his potential team selection by omitting several big names from the starting lineup for Rio Ferdinand's testimonial match against Sevilla this evening.
One of those is Wayne Rooney, but the wantaway England striker is also likely to miss out at Wembley, with doubts over his fitness and his long-term future with United.