Head coach Ole Gunnar Solskjaer revealed on Friday afternoon that Paul Pogba, Juan Mata and Phil Jones remain unavailable for selection, while David de Gea has returned to Spain for the birth of his child, meaning that Dean Henderson will retain his spot between the sticks.
Victor Lindelof was not involved against the Eagles as he battles a back problem, but the Sweden international is expected to return to the starting XI at the Etihad Stadium.
Daniel James has been in strong form for the Red Devils in recent weeks, and the fact that the Wales international was not named in the XI against Palace suggests that he will be involved from the start here, potentially at the expense of Mason Greenwood.
Solskjaer does have the option of selecting Greenwood through the middle and dropping fit-again Edinson Cavani down to the bench.
However, the Uruguay international should be preferred from the start, with the likes of Greenwood, Amad Diallo and potentially Martial providing the attacking options on the bench.
However, the Norwegian is expected resist the temptation to change his formation as Man United attempt to stretch their unbeaten Premier League away record, which currently stands at 21 matches.
Man United possible starting lineup: Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; James, Fernandes, Rashford; Cavani
Watch the Sports Mole Football Shorts prediction for this game below: