Meanwhile, Ole Gunnar Solskjaer's side have enjoyed a nine-game unbeaten run in all competitions as they lie fifth in the table, and will be looking to emulate their 2-1 win over the Citizens at the Etihad Stadium back in December.
Here, Sports Mole has selected its strongest combined XI from the two Manchester rivals, using only players likely to be involved at the weekend.
The goalkeeping spot was a particularly tough choice for this fixture, with both Ederson and David de Gea up there with the best keepers in the world. However, the United number one has often been criticised for his performances this season, despite saving his side on many occasions throughout his Old Trafford career. Ederson's distribution and ability with the ball at his feet are unparalleled, and therefore the Brazilian edges out De Gea for this selection.
Fernandinho has often deputised as a centre-back in Laporte's absence, keeping out John Stones and Nicolas Otamendi in the process, and partners United captain Harry Maguire who gets the nod over Eric Bailly and Victor Lindelof. Maguire is a minor doubt for the weekend's derby, but is unlikely to face a significant spell out injured.
Aaron Wan-Bissaka has proven his defensive capabilities at United since his £50m switch from Crystal Palace, but Kyle Walker's attacking contributions and improved performances have seen him keep Joao Cancelo out of the City team, and therefore the former Tottenham Hotspur man occupies the right-back role.
A similar story at left-back sees Benjamin Mendy edge out Luke Shaw and Brandon Williams for this selection. The United pair have impressed under Solskjaer, but Mendy has offered a bit more going forward as well as greater experience.
Rodri has been a consistent performer in the holding role for Guardiola's side this season, and has also contributed three goals and one assist for the current Premier League champions. Fred and Scott McTominay have performed well as a midfield duo for the Red Devils, but neither are quite at the level of Rodri.
The Portugal international's form sees him partner Kevin De Bruyne in the midfield, and while the Belgian is a doubt for the weekend, Guardiola has affirmed that the 28-year-old is feeling better and in training. Bernardo Silva and David Silva were both worthy mentions for this selection, but De Bruyne has registered eight goals and 16 assists for City and has arguably been the best player in the league this season.
With regards to the front three, Sergio Aguero remains in the hunt for the golden boot with 16 goals in the 2019-20 campaign, and gets the nod over teammate Gabriel Jesus and United loanee Odion Ighalo.
Marcus Rashford's injury has led to Anthony Martial being tasked with scoring the bulk of United's goals, and the Frenchman has responded well to that responsibility with 10 goals and three assists from 22 matches to earn the final spot in this team.