Just a point will confirm the Red Devils as Group A champions, while an incredible seven-goal defeat is the eventuality that would see them exit the competition.
Paul Pogba will serve a three-game domestic ban for seeing red during the 3-1 win at Arsenal over the weekend but is cleared to start in the middle of the park tonight alongside the returning Ander Herrera and Daley Blind.
Shaw makes his first appearance for United since the end of October on the left of a back four alongside Antonio Valencia, Chris Smalling and Victor Lindelof, while Sergio Romero replaces David de Gea between the sticks ahead of Sunday's vital Manchester derby.
As for the hosts, manager Viktor Goncharenko makes two enforced changes following his side's 6-0 demolition of Tosno in the Russian Premier League last Friday.
Manchester United: Romero; Valencia, Smalling, Lindelof, Shaw; Herrera, Blind, Pogba; Mata, Lukaku, Rashford
Subs: Perteira, Darmian, Tuanzebe, Young, McTominay, Lingard, Martial
CSKA Moscow: Akinfeev; Fernandes, V. Berezutskiy, Ignashevich, Vasin; Nababkin, Kuchaev, Golovin; Vitinho, Chalov, Dzagoev
Subs: Pomazun, Makarov, Gordyushenko, Zhamaletdinov, Khosonov, Olanare
Keep up with every twist and turn of the action from Old Trafford this evening with Sports Mole's live text commentary here.