Melbourne City cruised to a comfortable 3-0 win back in December's reverse fixture, but victory for Macarthur this weekend would see them close the gap on the league leaders to just one point.
Macarthur failed to end their winless run in the A-League last time out as they were held to a 2-2 draw by Newcastle Jets.
That was Macarthur's first point in three games as they went into the game off the back of successive defeats against Brisbane Roar and Adelaide United.
Their dip in form has seen Macarthur drop to fifth in the A-League table, two points ahead of Western Sydney Wanderers in the final playoff spot.
On the other hand, Melbourne City continued their hunt for a first A-League title with a resounding 7-0 win over local rivals Melbourne Victory last time out.
With 31 points from 16 games, Patrick Kisnorbo's men remain at the top of the table, one point ahead of Central Coast Mariners.
Melbourne City have two games in hand over some of their A-League rivals and will be confident of pulling clear at the top of the table in the coming weeks.
Macarthur will be without the services of 31-year-old defender Aleksandar Jovanovic, who is out with a calf injury.
He is joined on the treatment table by right-back Ivan Franjic, who is suffering from a similar calf problem.
Despite the draw, Macarthur were impressive last time out, and Ante Milicic could opt to stick with the same starting XI.
Nathaniel Atkinson has been ruled out for the rest of the season after picking up a hamstring injury in the 3-2 win over Wellington Phoenix and other than that, Melbourne City have no injury concerns.
Jamie Maclaren just cannot stop scoring currently and has hit 19 goals in 16 outings this season.
The ever-present striker has played every single minute for the visitors this season and will once again spearhead their attack on Saturday.
Macarthur possible starting lineup:
Federici; Golec, Milligan, Susnjar; Li Rose, Benat, Genreau, Oar; La Rose, Derbyshire, Hollman
Melbourne City possible starting lineup:
Acton; Traore, Ryan, Ansell, Roux; Barnett, Butterfield; Brimmer, Kruse, McManaman; Folami
We say: Macarthur 1-3 Melbourne City
Macarthur have been decent on home turf this season, picking up three wins and three draws from nine games. However, considering the fact that the visitors are scoring freely at the moment, we are backing them to outscore the hosts and claim all three points in this one.