Les Gones ended 2020 at the top of the pile following a 3-0 victory over Nantes, and Lens also won their final game of the year as they overcame Brest 2-1.
Having struggled for consistency at the beginning of the campaign, Lyon are now well on their way to a first Ligue 1 triumph since the 2007-08 campaign.
Rudi Garcia's side rounded off 2020 with a resounding win against a struggling Nantes side on December 23, with Karl Toko Ekambi, Tino Kadewere and Lucas Paqueta putting the game to bed before half time at the Groupama Stadium.
Lyon's seventh win from their last eight matches ensured that they would be leading the way heading into the New Year, but only a solitary goal separates Les Gones and second-placed Lille - who have also accrued 36 points from 17 matches - in the standings.
The table-toppers will now be aiming to stretch their unbeaten run in the French top flight to 15 games, and no team has managed to prevail on Lyon's turf so far in the 2020-21 campaign.
However, anything other than a victory opens the door for Lille or Paris Saint-Germain to leapfrog Lyon on Wednesday, and even a win may not be enough to remain top if Lille can notch up more goals and triumph over Angers.
Meanwhile, Lens' impressive 2020 ended in perfect fashion with a 2-1 win over Brest - a result which saw them finish the year in the top seven following Montpellier's defeat to Lille.
Arnaud Kalimuendo and Florian Sotoca got the goals which propelled Franck Haise's men to their eighth victory of the season, and the Sang et Or faithful have plenty of reasons for optimism if Lens' 2021 is every bit as successful as their 2020 was.
Despite being tipped by many to make an immediate return to the second tier, Lens are firmly in the argument for a European berth and are level on points with sixth-placed Monaco - who have played a game more - and four points adrift of fourth-placed Rennes with a game in hand.
Lens have made a habit of losing one then winning one in the top flight recently, and while many will be expecting that run to continue here with defeat to Lyon, Lens have managed to prevail away from home against Rennes and Monaco already this season.
This week's visitors have only triumphed three times in their last 17 matches against Lyon, who eased to a 2-0 victory in this fixture when the sides last met in the 2014-15 campaign.
Lyon Ligue 1 form: WWWDWW
Lens Ligue 1 form: LWLWLW
The visitors have little in the way of injury concerns, although Manchester United-linked defender Facundo Medina is doubtful after missing out against Brest with a knee problem.
Cheick Traore is Lens' only long-term absentee as he recovers from an Achilles tendon rupture, and a number of changes could be on the cards with Issiaga Sylla, Jonathan Clauss and Gael Kakuta all in line for starts.
Lyon possible starting lineup:
Lopes; Dubois, Diomande, Denayer, Cornet; Mendes, Aouar, Paqueta; Cherki, Depay, Kadewere
Lens possible starting lineup:
Leca; Gradit, Bade, Fortes; Clauss, Doucoure, Fofana, Sylla; Kakuta; Sotoca, Kalimuendo
We say: Lyon 3-1 Lens
Lens have proved themselves as a force to be reckoned with away from home, with Rennes and Monaco both failing to break Haise's men down so far. The loss of Toko Ekambi is sure to harm Lyon's goalscoring prospects, but the league leaders should still have too much quality for the visitors and will be expected to pick up where they left off with a resounding victory this week.