Jurgen Klopp makes two changes from the side that suffered a 1-0 defeat to Chelsea at Stamford Bridge last weekend, with just one point required today to beat the Blues to Champions League qualification.
The first change comes at right-back, with Trent Alexander-Arnold dropping back to cover for Nathaniel Clyne alongside Dejan Lovren, Virgil van Dijk and Andrew Robertson ahead of Loris Karius in goal.
Jordan Henderson earns a recall in the middle of the park alongside Georginio Wijnaldum as James Milner drops out, while youngster Dominic Solanke comes into the attacking mix as Sadio Mane, Roberto Firmino and Mohamed Salah all start.
As for the visitors, Chris Hughton makes four changes following a 3-1 defeat away at champions Manchester City on Wednesday night, with Jurgen Locadia and Solly March coming in to join Anthony Knockaert up front.
Liverpool: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Wijnaldum; Mane, Salah, Firmino; Solanke
Subs: Mignolet, Clyne, Klavan, Moreno, Lallana, Ings, Woodburn
Brighton & Hove Albion: Ryan; Schelotto, Duffy, Dunk, Bong; Stephens, Kayal, Propper; Knockaert, Locadia, March
Subs: Krul, Bruno, Goldson, Suttner, Gross, Ulloa, Murray
Keep up with all of the action from Anfield this afternoon with Sports Mole's live text commentary here.