An unbeaten pre-season, matched with shrewd signings by McCarthy, meant Ipswich's fans began the new campaign with plenty of optimism. That balloon full of hope will well and truly be popped if the Lions leave Suffolk with all three points.
An opening-day defeat at promotion favourites Reading has since been followed by a tame exit in the Capital One Cup to Stevenage and a return to their home ground should help the Tractor Boys find their feet.
McCarthy has problems all the way up the left side with left-backs Aaron Cresswell and Tyrone Mings injured along with midfielders Anthony Wordsworth and Jay Tabb, who scored against former club Reading but came off with a rib injury against Stevenage.
The league campaign didn't begin perfectly as newly-promoted Yeovil, favourites for the drop, came to East London and left with the points thanks to Ed Upson's late winner.
In the same fixture between these sides last season, Ipswich came out on top 3-0 in December.
Possible starting lineups
Ipswich: Loach; Hewitt, Chambers, Berra, Smith; Edwards, Skuse, Hyam, Anderson; Murphy, McGoldrick
Millwall: Bywater; Dunne, Shittu, Beevers, Lowry; Henry, Wright, Abdou, Chaplow; McDonald, Morison
Sports Mole says: 2-0