The league's bottom side will be looking to push on from their victory last time out, sticking with the same lineup that overcame Ross County on the weekend.
Ex-Jambo keeper Marian Kello starts in goal for the Saints, returning to a ground he knows well having spent four years at Hearts.
Hearts: MacDonald, McGowan, McKay, Wilson, McHattie, Smith, Hamill, Robinson, Nicholson, Carrick, Paterson
Subs: Ridgers, B.King, Tapping, McGhee, Beith, Oliver
St Mirren: Kello, Naismith, McAusland, McGregor, Kelly, Newton, McGinn, Goodwin, McGowan, Campbell, Thomson.