The Colombia international was not included in the squad for Sunday's 1-0 home defeat to already-relegated Sheffield United due to the issue, with manager Carlo Ancelotti unlikely to risk his fitness at this stage of the season.
Joshua King is unlikely to play for the club again due to a back problem ahead of his contract expiring in the summer, while Jean-Philippe Gbamin and Tyler Onyango have been ruled out for the rest of the season.
Having used a back five in recent weeks, Ancelotti may be tempted to revert to a back four given his side's need to win on Wednesday to keep their slim aspirations of competing in Europe next season alive.
Mason Holgate was substituted for Gylfi Sigurdsson at half time of the hapless defeat to Sheff Utd, and that switch could be made from the start against Wolves in order to get an extra attacker onto the pitch.
That could mean slightly wider roles for Richarlison and James Rodriguez in support of Dominic Calvert-Lewin, who will be hoping to end the season a high in order to confirm his place in England's Euro 2020 squad this summer.
Everton possible starting lineup: Pickford; Coleman, Godfrey, Keane, Digne; Doucoure, Allan; Rodriguez, Sigurdsson, Richarlison; Calvert-Lewin
Watch the Sports Mole Football Shorts prediction for this game below: