That is certainly a big loss for manager Martin Lasarte, given Sanchez leads Chile's all-time scoring charts with 46 international goals in 138 games.
However, the rest of their side is largely the same as it has been for the last few international tournaments, with Lasarte sticking with the experienced spine of goalkeeper Claudio Bravo, centre-back Gary Medel, midfielder Arturo Vidal and forward Eduardo Vargas, each of which have made over 95 appearances for their nation.
It was Medel's centre-back partner Guillermo Maripan that shone in their opening draw with Argentina, as he was a rock at the back, rarely affording any opportunities to a dangerous attacking line.
Vargas will once again lead the line in Sanchez's absence, having netted the goal to earn his nation a point last time out, as he pounced on the rebound to find the net after Emiliano Martinez had saved Vidal's penalty.
Chile possible starting lineup: Bravo; Isla, Medel, Maripan, Mena; Vidal, Pulgar, Aranguiz; Palacios, Vargas, Meneses