The Blues are currently fourth in the Premier League table and they face a battle with London rivals Arsenal and Chelsea, as well as Everton, for a place in next season's Champions League.
Interim manager Rafael Benitez may make a number of changes to the team that lost in the FA Cup to Manchester City at the weekend. As a result, that may mean that the likes of John Terry, Frank Lampard and Fernando Torres will all be included.
Meanwhile, injury is likely to rule former Chelsea winger Damien Duff out of a return to Stamford Bridge. His place in the Fulham team could go to Bulgarian winger Stanislav Manolev, while John Arne Riise may also be recalled.
The last five encounters between these two teams have ended in draws, with neither side having managed to score more than one goal during those encounters.
Possible starting lineups
Fulham: Schwarzer; Senderos, Hangeland, Riise, Riether; Karagounis, Manolevm, Emanuelson, Frimpong; Berbatov, Ruiz
Chelsea: Cech; Ivanovic, Luiz, Terry, Bertrand; Lampard, Mikel; Mata, Oscar, Moses; Torres
Sports Mole says: 2-1