Watford vs. Chelsea (Wednesday, 7.30pm)
While Thomas Tuchel's side were held to a 1-1 draw by Manchester United, the Hornets went down 4-2 to Leicester City in tough conditions.
We say: Watford 0-2 Chelsea
Any hopes of Watford repeating their recent 4-1 thrashing of Man United or similar 2018 success against the Blues will surely be dashed here, with Ranieri's depleted outfit no match for a freshened-up Chelsea.
Tuchel's side have conceded just one goal on the road all season and have bountiful options for rotation in the final third, so we can only envisage the Blues returning to winning ways comfortably.
Wolves vs. Burnley (Wednesday, 7.30pm)
Meanwhile, fresh off the back of a weekend off, the Clarets travel to Molineux currently sitting three points adrift of safety at the wrong end of the table.
We say: Wolverhampton Wanderers 1-1 Burnley
With Wolves continuing to struggle for goals, it is difficult to back Lage's side with any level of certainty. With that in mind, we are going to predict a low-scoring draw, Burnley benefitting from their fresher legs.
Southampton vs. Leicester (Wednesday, 7.30pm)
While the Saints were being torn apart by Jurgen Klopp's men, the Foxes prevailed in a 4-2 goal-fest with Claudio Ranieri's Watford.
We say: Southampton 1-1 Leicester City
Going down 4-0 to Liverpool should not be a trigger for Southampton to press the panic button, especially given how defensively sound they have been on home soil so far this term.
It is difficult to know what to expect from this inconsistent Leicester side - except for goals at both ends in away fixtures - and we can see a refreshed Southampton XI coming away with a respectable point.
West Ham vs. Brighton (Wednesday, 7.30pm)
While the Hammers remain in fourth position in the standings, Brighton are down in ninth spot after failing to win any of their last eight top-flight fixtures.
We say: West Ham United 3-1 Brighton & Hove Albion
Despite Potter being relatively satisfied with the performances of his team, the Seagulls do not travel to East London in confident mood. That should contribute to a comfortable victory for the Hammers, who may seize control with a couple of early goals.
Everton vs. Liverpool (Wednesday, 8.15pm)
Two Merseyside rivals in very different veins of form renew hostilities for Wednesday's Premier League derby, as Everton and Liverpool face off at Goodison Park.
The Toffees went down 1-0 to Brentford last time out, while Jurgen Klopp's side eased to a 4-0 victory at home to Southampton.
We say: Everton 0-2 Liverpool
As the old saying goes, form goes out of the window when it comes to such a hotly-contested derby, and Everton's recent record against Liverpool at Goodison Park will certainly serve as encouragement.
Each of the last four meetings between the sides on the Toffees' turf has ended level, but a weakened Everton backline and misfiring attack are ill-equipped to take a point from this clash, with Klopp's men sweeping aside almost everything in front of them at present.
Aston Villa vs. Man City (Wednesday, 8.15pm)
The hosts saw off the challenge of Crystal Palace 2-1 at the weekend, while the Citizens beat West Ham United by the same scoreline.
We say: Aston Villa 1-2 Manchester City
City may have produced a number of goal-laden performances against Villa down the years, but this will be no cakewalk for the champions as the Gerrard revolution aims to gather momentum.
Guardiola's hand may be forced in a fatigued attack, but the visitors should still have enough to take all three points back to the Etihad.