Gladbach returned to action with a 3-1 victory over Eintracht Frankfurt last weekend, while Leverkusen thumped Werder Bremen 4-1 away from home on Monday night.
The eyes of the world were on the Bundesliga last weekend as the league resumed amid the coronavirus pandemic. All things considered, the first round of matches in more than two months was a success, and the authorities will be hoping for another smooth set of fixtures in the coming days.
Gladbach recorded a 2-1 home victory over Koln in March before the league was called to a halt and made it back-to-back victories with a 3-1 success away to Frankfurt last weekend.
Head coach Marco Rose will surely have been delighted with what he saw from his side on their return to action, and the 43-year-old will be eyeing another three points on Saturday afternoon.
Gladbach are currently third in the Bundesliga table, two points off second-placed Borussia Dortmund and just six behind leaders Bayern Munich on the same number of matches.
They have also won each of their last three league meetings with Leverkusen during a strong run of form, including a 2-1 success in the reverse fixture earlier this season.
Leverkusen, meanwhile, were also impressive on their return to action last time out, recording a 4-1 success away to Werder Bremen. The much-coveted Kai Havertz scored twice for Die Werkself, who are actually unbeaten in Germany's top flight since the start of February.
In fact, Peter Bosz's side have only lost one of their last 10 in the Bundesliga and have won five of their last six, scoring eight times in their last two victories.
Leverkusen are, without question, a side in excellent form, and they currently sit fifth in the table, just two points off third-placed Gladbach ahead of what is a very important fixture on Saturday afternoon.
There is still a lot of football to be played before the end of the season, but the fact that Bosz's team are just four points off second-placed Dortmund at this stage is impressive, and the former Champions League finalists will be eyeing their highest finish in Germany's top flight since claiming second in 2010-11.
Gladbach Bundesliga form: WDWLWW
Leverkusen Bundesliga form: WWWDWW
Leverkusen form (all competitions): WDWWWW
Patrick Herrmann came off the bench against Frankfurt and is in contention to start, although it would not be a surprise to see Rose send the same starting XI onto the field.
As for Leverkusen, Havertz, who continues to be linked with the likes of Manchester United, Liverpool and Barcelona, scored twice from the centre-forward spot against Werder Bremen and could well feature in that area of the field once again.
Gladbach possible starting lineup:
Sommer; Rainer, Ginter, Elvedi, Bensebaini; Neuhaus, Strobl; Plea, Hofmann, Thuram; Embolo
Leverkusen possible starting lineup:
Hradecky; Weiser, Tapsoba, Bender, Sinkgraven; Aranguiz, Demirbay; Diaby, Amiri, Wirtz; Havertz
We say: Gladbach 1-1 Leverkusen
This is a tough game to call for a number of reasons. Both teams will be full of confidence following their results last weekend, while the pair had been in strong form before the league was halted. All things considered, we are finding it hard to separate them and have therefore tipped a low-scoring draw.