Both teams have already qualified for the round of 32 and boast 12 points each, although Slavia Prague currently occupy top spot ahead of second-placed Leverkusen.
The loss of Kai Havertz to Chelsea has certainly not affected Leverkusen's goalscoring capabilities, with the German outfit notching up 17 goals in five group stage matches - the highest out of any team in this year's tournament.
Peter Bosz's men have only been kept at bay once in the 2020-21 edition, which happened in the Czech capital as Slavia enjoyed a 1-0 victory over their midweek opponents courtesy of a Peter Olayinka goal back in October.
Leverkusen have notched up at least three goals in their other four matches in Group C, and while the German outfit managed to thrash Nice 6-2 at home on the first matchday, last week's affair was much closer by comparison as Bosz's side scraped a 3-2 victory at the Allianz Riviera.
Nevertheless, that result confirmed Leverkusen's spot in the round of 32, and given how Die Werkself have performed both domestically and continentally, Bosz's side can be forgiven for harbouring dreams about European glory.
Bosz's men maintained their unbeaten start to the Bundesliga season at the weekend as they easily overcame Schalke 3-0, with Malick Thiaw turning into his own net before second-half goals from Julian Baumgartlinger and Patrik Schick made sure of the win.
Slavia Prague have also swept aside the competition in Group C with four wins and one loss so far, with the Czech giants' solitary defeat coming at the hands of Hapoel Be'er Sheva in their maiden game of the tournament.
Since that 3-1 defeat in Petah Tikva, Slavia recorded that narrow triumph over Leverkusen as well as two successive wins over Nice, and Jindrich Trpisovsky's men gained revenge over Be'er Sheva by winning 3-0 on their own turf against the Israeli outfit last week.
The Fortuna Liga champions can match Leverkusen's terrific spell of form with seven wins from their last eight in all competitions, and Slavia simply eased past Sparta Prague in the weekend's capital derby.
Nineteen-year-old Abdallah Sima bagged a first-half brace after Slavia goalkeeper Ondrej Kolar had saved from 12 yards, and Ondrej Lingr added a third in the second 45 to propel Trpisovsky's side to a resounding 3-0 victory over their bitter rivals.
If there is a victor in Thursday's tie between Leverkusen and Slavia, they will finish top of the group. If both teams walk away with a share of the spoils, Slavia will place first and Leverkusen will go through as runners-up.
Bayer Leverkusen Europa League form: WLWWW
Bayer Leverkusen form (all competitions): WWWDWW
Slavia Prague Europa League form: LWWWW
Slavia Prague form (all competitions): WWWDWW
Slavia do not have as many injury concerns to take into account for this one, but David Hovorka is yet to return from a knee injury he sustained on international duty last month.
Sima's double in the Prague derby took him up to 11 for the season in all competitions and he will look to keep that run going here, while Petar Musa and Nicolae Stanciu will be vying for spots in the visitors' first XI.
Bayer Leverkusen possible starting lineup:
Hradecky; Weiser, Tah, Tapsoba, Wendell; Baumgartlinger, Wirtz, Turkmen; Bellarabi, Schick, Diaby
Slavia Prague possible starting lineup:
Kolar; Holes, Kudela, Karafiat, Boril; Sevcik, Traore; Sima, Stanciu, Olayinka; Musa
We say: Bayer Leverkusen 3-1 Slavia Prague
Both of these sides are in excellent form and boast youthful quality in attack, but with Leverkusen and Slavia already guaranteed to go through, the two managers need not take any unnecessary risks in search of a win. Rotation is likely to be on the cards, and while Leverkusen certainly should not be underestimating the visitors, we still expect the Bundesliga giants to march to victory and finish atop the rankings in Group C.