Alaves vs. Celta Vigo (Saturday, 1.00pm)
The hosts will be hoping to claim their third successive home victory, while the visitors could extend their unbeaten away run to three games with at least a draw in Northern Spain.
We say: Alaves 2-2 Celta Vigo
Both Alaves and Celta Vigo will fancy their chances of securing all three points this weekend, though the visitors will head into this game with a slight psychological edge after winning each of the last three meetings.
The two teams played out score draws in their last league matches, and with little to separate them here, another could be on the cards at the Mendizorroza.
Valencia vs. Rayo Vallecano (Saturday, 3.15pm)
The hosts are unbeaten in each of their last four matches on home soil, while the visitors are hoping to avoid a fourth successive away defeat.
We say: Valencia 1-1 Rayo Vallecano
Both teams will feel that they are more than capable of claiming all three points from this fixture as they aim to climb further up the La Liga table.
However, with little to separate these two top-10 sides, a score draw could be on the cards at the Mestalla.
Mallorca vs. Getafe (Saturday, 5.30pm)
The hosts are unbeaten in each of their last three league games on home soil, while the visitors are yet to win on the road so far this season.
We say: Mallorca 1-1 Getafe
Getafe's recent revival will see them head into Saturday's game in a more positive mood than Mallorca, though the hosts will fancy their chances of returning to winning ways against their relegation-threatened opponents.
A closely-fought contest is set to be played out at the Iberostar Stadium, which may see the two sides forced to share the spoils.
Villarreal vs. Barcelona (Saturday, 8.00pm)
The Catalan giants are currently seventh in La Liga, 10 points off leaders Real Madrid, while Villarreal occupy 12th, four points behind their opponents this weekend.
We say: Villarreal 1-2 Barcelona
Villarreal will be desperate to bounce back from the disappointment of the Man United result, and the Yellow Submarine have proved difficult to beat in La Liga this season. That said, Barcelona's record against Villarreal is so impressive, and we have a feeling that the Catalan outfit will shade a close contest.