The Blades are bottom of the table and 15 points from safety, while Villa look good value for a top-four charge, sitting just six points off the Champions League spots with a couple of games in hand.
Here, Sports Mole rounds up all of the latest team news for both sides.
Sports Mole's predicted XI: Ramsdale; Ampadu, Jagielka, Bryan; Baldock, Lundstram, Norwood, Fleck, Stevens; Mousset, Sharp
Sports Mole's predicted XI: Martinez; Elmohamady, Konsa, Mings, Targett; Luiz, McGinn; Traore, Barkley, El Ghazi; Watkins
Watch the Sports Mole Football Shorts prediction for this game below: