Alan Pardew's much-changed outfit secured a goalless draw in the first leg of the European tie, placing the Magpies in the driving seat as they attempt to become one of the final eight teams in the competition.
The home side will enter the match full of confidence having won three of their last five matches in all competitions, a run of form that has moved them into 13th position in the Premier League table and away from relegation trouble.
On the other hand, Anzhi have won just one of their last five in all competitions, with their latest league defeat to FC Mordovia Saransk leaving them in second position in the table, five points behind leaders CSKA Moscow.
Newcastle: Elliot; Simpson, Yanga-Mbiwa, Perch, Santon; Cabaye, Tiote, Anita; Sissoko, Marveaux, Ben Arfa
Anzhi: Gabulov; Eschenko, Chaves, Ewerton, Jucilei; Shatov, Zhirkov, Akhmedov, Diarra; Willian, Eto'o
Sports Mole says: 1-2