Pakistan have halted England's progress with the bat by taking three wickets in the morning session of day three in the third and final Test in Sharjah.
James Taylor and Jonny Bairstow put on an impressive display to close day two on 222 runs with the loss of four wickets.
However, their partnership came to an end five overs into day three as Taylor was dismissed for 76 off the bowling of Rahat Ali.
Sarfraz Ahmed also played a part as he took an impressive low catch to give Pakistan, who currently lead the series 1-0, some momentum.
England were in trouble again when Bairstow was bowled out by Zulfiqar Babar seven runs short of a half-century.
On the stroke of lunch, Adil Rashid was removed by Shoaib Malik following a catch from Azhar Ali at short leg.
Trevor Bayliss's side trailed by 12 runs before the start of play, but they now have a 51-run lead and sit 285-7.
Samit Patel is unbeaten on 41.
Danielle Joynson
