Captain Alastair Cook, James Anderson, Graeme Swann, Ian Bell and Broad will all sit out the ODI series with Australia as England look to rest a number of key players ahead of this winter's Ashes series.
Former England skipper Vaughan claimed that fans deserve a partial refund due to the number of players missing the series but Broad was quick to dismiss those suggestions.
"I think [Vaughan's comments are] disrespectful to the side that's going to go out on the field," Broad told reporters.
"There are guys who have performed throughout the county season to get a chance at the international level.
"As an ODI team, we're building towards that 2015 World Cup where you need to have a big group of players going into it with experience of international caps."
England face Australia in the first of two Twenty20 matches tomorrow evening.