McGuigan is a former world featherweight champion, but the Irishman has revealed that he expects the unbeaten 26-year-old to become a "global star" in the sport.
The 52-year-old told BBC Sport: "He's got more natural ability than me. He's got enough talent and power to win world titles from 122lb to 130lb. He can become a global boxing star."
"He hasn't got my pace and pressure, but he can box going forward and going back and he's got more single-punch power than me."
Frampton faces Frenchman Jeremy Parodi in a final world title eliminator on Saturday night.