Knight responded to a tweet from Khan about people not being brave enough to slate him to his face, before contesting Malignaggi's claims that he was the "twitter king".
"Oi you go to sleep anytime anyone confronts you. so that makes you the pussy. Lol," Knight tweeted. "Dick head thinks anyone is hating on him going to sleep in front of millions of people. Cut it out Khan, York hall for your next fight lol.
"I aint trying to fight Khan in the ring but bring him on a football pitch and watch me chopper Harris is whole life lol."
Knight then turned his attention to Malignaggi, in particular referencing his loss to Khan.
"Someone tell paulie he can't be tweet king when he's getting stopped by a sleep walker. Your a pro boxer with no followers and if u think khan & Hatton hurt u ... I'll fully flatline u on here. This guy is a fruity fraud ... The boxing world don't even take him serious he's a top fighters warm up fight. Sit down Paulie lad your done," wrote Knight.
Malignaggi responded to Knight by claiming that he didn't know who he was, while the former Chelsea man pointed out that he had more followers than the boxer.
Malignaggi then poked fun at Knight's height, saying: "I am seeing @LeonKnight82 is about 5 foot tall LMFAOO...#grownmanproblems HAHAH If you want to argue with me on twitter, must be 5'6 #TK.
"Can @LeonKnight82 get on a rollercoaster?"
Knight then floated the idea of a charity fight between the two, to which Malignaggi responded: "I would never fight @LeonKnight82 he comes up to my knees. I have a height requirement."
Knight is developing something of a reputation for his social media clashes, having recently clashed with Jamie O'Hara.