A clash between the two welterweight fighters has been anticipated for some time but their respective teams have never been able to agree terms for what would be considered a super-fight in Great Britain.
However, while Khan has acknowledged that discussions are taking place, he has indicated that he is looking past Brook - the current IBF champion.
The 30-year-old told Badlefthook.com: "That fight between me and him can happen, I mean I do consider it.
"I don't mind having that as a tune-up fight - the Kell Brook fight - before I go into big fights, so we [are] in talks, I've left it to my team. I have a great team in the UK now."