Lowry partnered with DeMar DeRozan to score 46 points together, including 14 in the final segment, in order to overturn a 14-point deficit and win the game.
"We have a good team and a group of guys who are very resilient," Lowry told reporters after the match.
"We want to win games and we have a goal in mind. It's fun to win games and when you've found the recipe to win in the fourth, you have to stick with it."
The victory sees the Raptors sitting in first position in the Atlantic Division, with a record of 39-30 for the season.