Five players were able to make it into double figures for Miami away from home, with Chris Bosh leading the way with 14 points at the BMO Harris Bradley Center.
"It's a great trip. A great trip. It sucked on Wednesday; we wanted that one," James told reporters.
"We really wanted that game in Indy. But it's a great trip overall. Just how we bounced back with all the adversity as far as guys not in the lineup.
"True, true professional road trip, especially with these last two games."
The win sees the Heat sitting in first position in the Southeast Division with a record of 50-22 for the season.