Golden State, who are the defending champions, eclipsed the previous record of 15-0 held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
Reigning MVP Stephen Curry top-scored with 24 points and also dished out nine assists, while no Laker put up more than 10 points and Kobe Bryant struggled with four points on 1-14 shooting.
Two teams on three-game losing streaks met at Pepsi Center and it was the Los Angeles Clippers who returned to winning ways with a 111-94 success over the Denver Nuggets.
Danilo Gallinari impressed for the Nuggets with 20 points and a career-high 18 rebounds, but a balanced team performance from the Clippers, with Blake Griffin and DeAndre Jordan both scoring 18, helped the visitors to victory.
Point-guard Rose scored 17 points, while Jimmy Butler had 22 that included a half-court buzzer-beater that put the Bulls nine points ahead at half time.
Results in full: Indiana Pacers 123-106 Washington Wizards, Boston Celtics 97-121 Atlanta Hawks, Dallas Mavericks 96-110 Memphis Grizzlies, Los Angeles Clippers 111-94 Denver Nuggets, Chicago Bulls 93-88 Portland Trail Blazers, Los Angeles Lakers 77-111 Golden State Warriors