The Atlanta Hawks continued their franchise-best winning streak by overcoming a scare to beat the Philadelphia 76ers 91-85.
Atlanta wasted a 21-point advantage to allow the Sixers to fight back in the fourth quarter, but Al Horford, who scored 23 points, guided the Hawks to victory in the closing stages.
Wiggins, who left the Cavaliers in a trade which saw Kevin Love move in the opposite direction in the summer, scored 33 points, but James registered 16 of his 36 points in the fourth quarter to guide the Cavaliers home.
Successive defeats for the Golden State Warriors were put behind them as Stephen Curry led the Western Conference leaders to a comfortable 106-87 win over the Phoenix Suns.
The Warriors led by just one point at half time, but Curry finished with 25 points and Klay Thompson added 22 more to hold off the Phoenix challenge.
Randolph's 12th straight double-double included 21 points and 18 rebounds as the Thunder fell to 23-24 for the season.
Twenty-eight points each from Kentavious Caldwell-Pope and D.J. Augustin guided the Pistons over the line as the Rockets failed to capitalise on 26 points, seven rebounds and nine assists from MVP candidate James Harden.
Jared Dudley scored 18 points and O.J. Mayo registered 17 off the bench to add to Portland's problems as they have now lost three successive games.
Al Jefferson and Jason Maxiell added 14 points each for the Hornets, whose fine form continued with a 10th win in 13 games.
Kawhi Leonard top scored for the champions with 24 points, but Griffin's contribution and 20 points from Chris Paul made the difference as the Clippers ended a four-game losing streak against the Spurs with a 105-85 win.
Results in full: Philadelphia 76ers 85-91 Atlanta Hawks, Cleveland Cavaliers 106-90 Minnesota Timberwolves, Phoenix Suns 87-106 Golden State Warriors, Toronto Raptors 120-116 Washington Wizards, Dallas Mavericks 108-93 Orlando Magic, Oklahoma City Thunder 74-85 Memphis Grizzlies, Houston Rockets 101-114 Detroit Pistons, Sacramento Kings 99-94 Indiana Pacers, Milwaukee Bucks 95-88 Portland Trail Blazers, Charlotte Hornets 104-86 Denver Nuggets, Los Angeles Clippers 105-85 San Antonio Spurs