Luck broke a number of NFL rookie records during his debut season last year, prompting some to claim that he could go on to emulate the achievements of Manning, who is considered to be the best player in the franchise's history.
Wayne, who has played with both quarterbacks, sees similarities in how they approach training and has been im6pressed with the way Luck has taken control of the offence.
"The way [Luck] approaches practice, I hate to do this, but it's somewhat like a Peyton Manning," Wayne told NBC Sports.
"Even though I hate to compare the two, he takes practice just like it's a game. He knows as well as I do that practice is probably going to be harder than the games because you're going to see it so many different ways. In game time, you may only see it once or twice.
"He gets us in and out of the huddle, he tells us to pick it up, he tells the offensive line, 'Hey, we need to do better here.' He tells the receivers, 'I need you to come out a little higher' or whatever the case may be. So he's on it. Whenever your quarterback is doing that, you know you're in the right direction. So I'm glad to see him doing that."
Luck was the first pick in the 2012 Draft and went on to guide the Colts to the playoffs last season.