The 52-year-old sank to the ground as the two teams walked off the field for half time and was stretchered off after being attended to by medical staff.
Early reports have not specified the exact problem, although NBC have confirmed that it was not a heart attack.
Meanwhile, the Texans have announced that he did not lose consciousness and was talking to doctors treating him.
The incident follows on from that of Denver Broncos head coach John Fox, who will require heart surgery after collapsing while playing golf yesterday.
Update: Coach Kubiak has been taken to a local hospital, he is conscious and his family is with him. #TexansGameday— Houston Texans (@HoustonTexans) November 4, 2013