Manning was hit a number of times by the Chargers defense throughout the match, included a low hit by defensive end Corey Liuget with just 1:44 left to play that forced the veteran to receive treatment on his ankle.
The 37-year-old will now undergo a scan on that right ankle as well as his knee, and he hopes that it is not an injury that he will be forced to carry for the rest of the season.
"I'm pretty sore. They got me twice in that lower area. I felt better coming into the game after the bye week, but I'm pretty sore," Manning told The AP.
"Lower body, [I] feel like the injury report is very revealing to the opponent as well as the folks in Vegas, so I guess somewhere in that lower body.
"I'd like to be able to shake it. It's just what the docs said, and I had [an MRI scan] a couple weeks ago. And so took a couple hits today, so just kind of update to see what it says. Hopefully it's no change."
Manning threw for 330 yards and four touchdowns in the victory, which left the Broncos 8-1 for the season.