The Germany international was forced to sit out the Gunners' last three games due to illness, but he has fully recovered in time to take the place of Francis Coquelin.
Gabriel Paulista also comes in from last time out in the league, replacing the injured Hector Bellerin in a rejigged backline, while Theo Walcott, Mohamed Elneny, Santi Cazorla, Per Mertesacker and Kieran Gibbs are all absent.
In terms of the home side, who have won three of their last five meetings with Arsenal, boss Paul Clement has made two changes for his first official top-flight game in charge.
Swansea City: Fabianski; Naughton, Fernandez, Mawson, Kingsley; Ki, Sigurdsson, Cork; Dyer, Llorente, Routledge
Subs: Nordfeldt, Ranger, Van der Hoorn, Fer, Fulton, Borja, McBurnie
Arsenal: Cech; Koscielny, Mustafi, Gabriel, Monreal; Xhaka, Ramsey; Sanchez, Ozil, Iwobi, Giroud
Subs: Ospina, Maitland-Niles, Holding, Reine-Adelaide, Oxlade-Chamberlain, Lucas, Welbeck
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