Centre Jamie Roberts has said that the injuries to Rhys Webb and Leigh Halfpenny are a "huge blow" to Wales's Rugby World Cup hopes.
"It's a blow, there's no doubting that," Roberts told Sky Sports News. "They're two quality players, two first-team players. It's a huge blow.
"The qualities of both of them shouldn't be under-estimated. They're two quality lads who bring a lot to the team and the squad environment. The timing of this one is desperately unfortunate.
"It's a big blow - two wonderful players, first-team players, who've been instrumental in our success in the past few years. It's difficult. It'll test our strength in depth, but this is why Warren [Gatland] has bred strength in depth in the past few years. We have to be ready for moments like this."
Wales start their Rugby World Cup campaign against Uruguay on September 20.