The home side will still be without a number of their regular players because of the Six Nations, but Adam Powell, Mako Vunipola and Will Fraser are among those coming back in to the starting lineup, as Sarries look to put their 29-16 loss to London Irish last weekend behind them.
The game will be the first in the history of the Premiership to take place on an artificial pitch.
Saracens: Wyles, Short, Tomkins, Powell, Strettle, Hodgson, deKock, Joubert, Fraser, Wray, Botha, Borthwick, Stevens, Smit, Vunipola
Exeter: Arscott, Nowell, Whitten, Shoemark, Jess, Steenson, Chudley, Horstmann, Scaysbrook, Baxter, Welch, Mumm, Tui, Clark, Moon
Sports Mole says: A narrow win for Saracens