For the visitors, as well as the return of Yarde, Sailosi Tagicakibau replaces Jonathan Joseph and Darren Allinson makes his first start of the season at scrum half.
George Skivington is fit for Irish, however he only makes the replacements.
Sale: Macleod, Cueto, Leota, Tuitupou, Shepherd, Cipriani, Willis, Harrison, Taylor, Buckley, Gray, McKenzie, Vernon, Seymour, Powell
Replacements: Ward, Lewis-Roberts, Cobilas, Myall, Easter, Peel, Miller, Brady
London Irish: Watson, Ojo, Armitage, Tagicakibau, Yarde, Humphreys, Allinson, Lahiff, Lawson, Aulika, Evans, Garvey, Danaher, Gibson, Hala'ufia
Replacements: Blaney, Griffiths, Halavatau, Skivington, Treviranus, Shingler, Geraghty, Moates