Meanwhile, Steve Diamond will be taking charge of the team for the remainder of the season in a bid to turn around their bad fortune.
Regardless of who's calling the shots, the Sharks are still in desperate need of points and have failed to notch up a win from their first seven league games of the season.
Their opponents on Friday have been enjoying victories in Europe, but domestic success has been less easy to come by and five defeats from their first seven matches has left them one place above Sale.
London Irish: WLWWWL
Sale: Macleod, Cueto, Leota, Tuitupou, Shepherd, Cipriani, Willis, Harrison, Taylor, Buckley, Gray, McKenzie, Vernon, Seymour, Powell
Replacements: Ward, Lewis-Roberts, Cobilas, Myall, Easter, Peel, Miller, Brady
London Irish: Watson, Ojo, Armitage, Tagicakibau, Yarde, Humphreys, Allinson, Lahiff, Lawson, Aulika, Evans, Garvey, Danaher, Gibson, Hala'ufia
Replacements: Blaney, Griffiths, Halavatau, Skivington, Treviranus, Shingler, Geraghty, Moates
Sports Mole says: A rejuvenated Sale to taste victory.