The Saints, who have won their last two league matches, come into the contest two points behind fourth-placed Gloucester Rugby.
Meanwhile, Irish have recently opened up a five-point gap between themselves and the relegation zone with three victories from four games.
Northampton: Foden, Wilson, Pisi, May, Elliott, Myler, Dickson, Van Velze, Dowson, Manoa, Day, Lawes, Mercey, Hartley, Tonga'uiha
Replacements: McMillan, Waller, Mujati, Sorenson, Nutley, Roberts, Lamb, Waldouck
Irish: Homer, Ojo, Armitage, Geraghty, Yarde, Humphreys, Phibbs, Fisher, Treviranus, Garvey, Evans, Skivington, Aulika, Lawson, Lahiff
Replacements: Paice, Yanuyanutawa, Halavatau, Low, Sinclair, Tagicakibau, Sa, Moates
Sports Mole says: Northampton to seal the points