Welsh come into the match on a run of four consecutive defeats that has seen them slip to within six points of the drop zone.
Sale, who are still five points off safety, have enjoyed a recent resurgence in the league with two wins from their last three matches.
London Welsh: LWLLLL
London Welsh: Arscott; MacKenzie, Tiesi, Parker, Scott; Henson, Davies; Montanella, Briggs, Ion; Mills, Corker; Balding, Cabello, Jackson
Replacements: Bateman, Bristow, Tideswell, Kulemin, Hills, Keats, Ross, Jewell
Sale: Shepherd; Amesbury, Leota, Tuitupou, Cueto; Cipriani, Cliff; Dickinson, Jones, Thomas; Gray, Holmes; Braid, Seymour, Gaskell
Replacements: Taylor, Harrison, Roberts, Powell, Vernon, Willis, Macleod, Addison
Sports Mole says: Sale to earn a vital victory