The visitors have endured a difficult start to life in the top flight, with four defeats from their first six matches leaving them in 10th place in the table.
They won't be expecting an easy ride this weekend when they come up against a Wasps side who have won their last three on the bounce.
London Welsh have also had a radical overhaul of their team which has Martin Purdy, Seb Jewell and Michael Hills as the only names who played in the recent win over Cavalieri Prato in the Amlin Challenge Cup. Tom Voyce will also make his debut in place of the injured Tom Arscott.
Wasps: Southwell, Varndell, Masi, Thomas, Wade, Robinson, Simpson, Vunipola, Haskell, Johnson, Wentzel,Launchbury, Taulafo, Lindsay, Payne
Replacements: Rhys Thomas, Swainston, Staibano, Cannon, Poff, Davies, Bell, Daly
Welsh: Voyce, MacKenzie, Parker, Jewell, Scott, Henson, Keats, Jackson, Hills, Mills, Corker, Purdy, Ion, Briggs, Montanella
Replacements: George, Bristow, Joly, Kulemin, To'oala, Runciman, Lewis, Ajuwa
Sports Mole says: Wasps to earn a hard-fought win