Brian Smith's men are currently second-bottom in the table following six defeats from their last seven outings.
However, their task of getting points on the board will be made difficult against a second-placed Sarries side who have triumphed in their last eight matches in all competitions.
Scott Lawson, George Skivington and Ian Humphreys all return for the hosts, while David Strettle, Will Fraser, George Kruis, Duncan Taylor and Joel Tomkins all feature for the visitors after international duty.
London Irish: LWWWWL
London Irish: Homer, Ojo, Joseph, Armitage, Yarde, Humphreys, Phibbs, Hala'ufia, Sinclair, Garvey, Evans, Skivington, Aulika, Lawson, Lahiff
Replacements: Mayhew, Yanuyanutawa, Halavatau, Gibson, Treviranus, Shingler, Geraghty, Moates
Saracens: Wyles, Maddock, Tomkins, Taylor, Strettle, Hodgson, De Kock, Joubert, Fraser, Kruis, Hargreaves, Borthwick, Stevens, Smit, Auterac
Replacements: Brits, Gill, Du Plessis, Botha, Wray, Wigglesworth, Mordt, Short
Sports Mole says: Sarries to increase Irish woes