Despite losing their last league game to Saracens three weeks ago, the defending champions got back in the winning habit with two victories in the Heineken Cup.
They'll come up against a London Irish side who appear to have overcome their early-season blip by putting together a run that has seen them win four of the last five in all competitions.
However, they still only sit one place above the drop zone and will be desperate to get some points on the board in front of their home fans this weekend.
Ugo Monye, Tom Casson and Tom Guest all return to the Quins starting lineup, while Anthony Watson will make his first league start for the hosts.
It's also a special occasion for Irish captain Declan Danaher, who will make his 250th appearance for the club.
Irish: Watson, Ojo, Joseph, Armitage, Tagicakibau, Humphreys, O'Leary, Hala'ufia, Gibson, Danaher, Garvey, Evans, Aulika, Paice, Lahiff
Replacements: Lawson, Griffiths, Halavatau, Low, Treviranus, Gray, Shingler, Allinson
Quins: Brown, Williams, Hopper, Casson, Monye, Botica, Care, Marler, Buchanan, Johnston, Kohn, Robson, Guest, Robshaw, Easter
Replacements: Ward, Lambert, Collier, Matthews, Fa'asavalu, Dickson, Clegg, Stegmann
Sports Mole says: Quins to prove too much for Irish