However, their hosts will be keen to get some points on the board having lost their previous two matches in the league.
Irish coach Brian Smith has been forced to make three changes to his side due to international commitments and injuries, with Tom Homer, Chris Hala'ufia and Bryn Evans all coming into the starting lineup.
London Irish: WWLLWL
London Irish: Homer, Ojo, Tagicakibau, Geraghty, Watson, Humphreys, Allinson, Hala'ufia, Gibson, Danaher, Evans, Garvey, Halavatau, Blaney, Lahiff
Replacements: Ellis, Palframan, Griffiths, Low, Gray, Gaston, Shingler, Moates
Exeter: Arscott, Nowell, Dollman, Shoemark, Jess, Steenson, Thomas, Baxter, Scaysbrook, Mumm, Hanks, Hayes, Rimmer, Whitehead, Sturgess
Replacements: Alcott, Moon, Tui, Muldowney, Johnson, Barrett, Mieres, Naqelevuki
Sports Mole says: Exeter to leave the Madejski with the points