Tigers director of rugby Richard Cockerill told BBC Sport: "It's a recurrence of his groin, which is not great. That was three weeks last time. That's going to be an issue for him, with us, and obviously with the autumn series.
"He just went to accelerate and he felt his groin go. The way he plays, you just can't play with that sort of problem."
England are due to face New Zealand on November 8, with fixtures against South Africa, Samoa and Australia also scheduled for next month.