Harlequins have made two changes to the side which beat the Leicester Tigers, naming Seb Stegmann and Tom Guest in place of Tom Williams and Maurie Fa'asavalu.
Saracens recall captain Steve Borthwick to the lineup, while George Kruis, Andy Saull and David Strettle all return from injury.
Former South Africa captain John Smit has been named on the Saracens bench.
A Harlequins win would see them move to the top of the current Premiership standings.
Harlequins: Brown, Stegmann, Hopper, Turner-Hall, Monye, Evans, Care, Marler, Gray, Johnston, Kohn, Robson, Guest, Robshaw, Easter
Saracens: Goode, Ashton, Tomkins, Barritt, Wyles, Farrell, Gill, Brits, Du Plessis, Borthwick, Hargreaves, Botha, Brown, Fraser, Joubert
Sports Mole says: Harlequins