Conor O'Shea's side have already beaten strugglers Sale twice in the Aviva Premiership this season.
Harlequins have named an unchanged lineup from the one that defeated Bath in the last round.
Quins: Chisholm, Williams, Lowe, Casson, Smith, Botica, Dickson, Guest, Wallace, Fa'asavalu, Matthews, Twomey, Collier, Buchanan, Lambert
Replacements: Ward, Marfo, Johnston, Browne, Trayfoot, Burns, Clegg, Walker
Sale: Macleod, Brady, Addison, Leota, Ingall, Cipriani, Fowles, Powell, Seymour, Gaskell, Holmes, McKenzie, Buckley, Jones, Dickinson
Replacements: Taylor, Harrison, Thomas, Ostrikov, Braid, Peel, Tuitipou, Cueto
Sports Mole says: Quins to lift the trophy