The West Country side kept up their 100% record in Pool 1 last weekend as they ran out 29-22 winners at the Madejski Stadium.
However, London Irish come into the match just two points behind in the standings.
London Irish: LWLLLL
Gloucester: Cook, Sharples, Tindall, Twelvetrees, Monahan, Burns, CowaN, Murphy, Dawidiuk, Harden, James, Hamilton, Savage, Qera, Morgan
Replacements: Britton, Wood, Knight, Kalamafoni, Cox, Robson, Molenaar, Thomas
London Irish: Homer, Ojo, Joseph, Armitage, Watson, Geraghty, Allinson, Lahiff, Paice, Aulika, Sandford, Evans, Low, Gibson, Hala'ufia
Replacements: Lawson, Yanuyanutawa, Halavatau, Garvey, Danaher, Tagicakibau, Shingler, Moates
Sports Mole says: Gloucester to bag the points