Liberec were clinical in their 3-1 win in Friuli, but despite this Di Natale is confident of overturning the result on Thursday evening in the Czech Republic.
"On the night we played better than them, but they had three or four chances and managed to convert them," Di Natale told reporters.
"I think we can overturn the result. If we play like we did at home and can cut out the errors then we can do it. It will be tough, but we will give everything we have."
The game kicks off at 6pm.