Ryan Mason's outfit, meanwhile, are aiming to secure European football for next campaign. Here, Sports Mole rounds up all of the latest team news for both clubs.
Out: Ben Davies (calf)
Sports Mole's predicted XI: Lloris; Doherty, Sanchez, Alderweireld, Reguilon; Lo Celso, Hojbjerg, Ndombele; Moura, Kane, Son
Sports Mole's predicted XI: Patricio; Hoever, Coady, Kilman, Ait-Nouri; Dendoncker, Neves, Moutinho; Traore, Silva, Podence
Watch the Sports Mole Football Shorts prediction for this game below: